The protective effect of β-cryptoxanthin against cyclophosphamide-induced lung injury in adult male albino rats

Abstract Background Cyclophosphamide (CYP) is an anticancer agent widely used in chemotherapy. It has been suggested that CYP causes toxicity many organs, including the lungs and testes. Many studies have indicated some antioxidants possible protective effects against CYP’s side effects. β-cryptoxanthin (BCX), a major carotenoid of potential interest for health, known its antioxidant activities. This study aimed to investigate effect BCX on CYP-induced lung injury rats using histologic biochemical methods. Methods Forty adult male albino were divided into 4 groups: Group I served as control group. II received orally dose mg/kg per day 7 days. III single (200 mg/kg) intraperitoneally (i.p.) 7th study. IV (CYP + BCX). On 8th experiment, tissues collected histopathological examinations. The levels malondialdehyde (MDA), myeloperoxidase (MPO), reduced glutathione (GSH), peroxidase (GSH-Px) superoxide dismutase (SOD) also determined all dissected tissues. Results Pretreatment with ameliorated morphological changes noticed group MDA MPO significantly decreased whereas those GSH, GSH-Px SOD increased. Conclusions provides by reducing oxidative stress pulmonary fibrosis.